The G. Harold and Leila Y. Mathers Foundation

The G. Harold and Leila Y. Mathers Foundation supports basic, but potentially transformational, science research. Since 1982, they have awarded over $350 million in grants.

Letters of Interest are reviewed during three annual cycles. Invitations to submit a full application issued based on that review. The second cycle of 2023 is due July 28 with an application submission date of September 29. Cycle three LOIs are due December 1 with an application submission date of March 1, 2024. Requests should be for no more than $600,000 – $750,000 over a three year period.

Eligibility

This grant is open to:

  • 501(c)3 nonprofit organizations
  • Educational institutions

Investigators are limited to one application per cycle. Universities and institutions are limited to four applications per cycle.

Allowable Expenses

Grant funds may be spent on:

  • Investigators’ salaries
  • Laboratory supplies
  • Indirect costs (no more than 10% of total)

Grant funds may not be spent on capital equipment, i.e. ‘bricks and mortar’ purchases.

Supported Fields

The Foundation has recently supported research in:

  • Immunology
  • Microbiomes
  • Genomics
  • Structural biology
  • Cellular physiology
  • Neuroscience

Applications will not be approved for research in:

  • COVID-19 related projects
  • Clinical trials
  • Drug discovery
  • Medical imaging technology
  • Electrical engineering technology development
  • Plant biology
  • Oceanography
  • Space exploration
  • Global warming

Application

Step 1: Letter of Interest

LOIs must include:

  • Preliminary goals
  • Discussion of previous, related work
  • Budget estimate
  • CV of Principal Investigator with history of published research

Step 2: Proposal

Proposals must include:

  • Specific goals of the project
  • Proof of concept, if appropriate
  • History of prior, related research
  • Plan and methodology for conducting research
  • Explanation of the unique nature of the project
  • Detailed budget with justification
  • CVs for all team members
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